PostDoc in Immunology (m/f/d)

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The Harrer lab is conducting translational research focused on immune responses in autoimmunity and viral infections. We are looking for a PostDoc (m/f/d) to join our team on a project investigating the immune cell receptor repertoire in patients with ME/CFS and Post-COVID-syndrome (PCS). Detection of functional GPCR autoantibodies correlates to fatigue in PCS patients but so far, it is unclear why only subgroups of patients responded to autoantibody targeting treatments. Therefore, additional biomarkers are needed to delineate the role of autoimmunity in ME/CFS and PCS and to monitor the effectiveness of immunomodulatory treatments. One promising strategy in this context is the analysis of BCR and TCR repertoire of ME/CFS and PCS patients to detect potentially expanded or autoreactive clones that can be targeted. The aim of the project is to investigate whether scRNA-seq of the immune receptor repertoire is capable of detecting autoimmune reactions in patients with ME/CFS and PCS and of assessing their response to immunomodulatory therapies.