PhD position (m/f/x) (for 3 years)
Mikrobiologie
25.025 hours
Fixed term of 36 months
as of 01.01.2025
Eingruppierung gemäß
TV-L
Application deadline 15.09.2024
Universitätsklinikum Erlangen
Institut für Klinische Mikrobiologie, Immunologie und Hygiene
Prof. Dr. Christian Bogdan
Wasserturmstraße 3-5
D-91054 Erlangen, Germany
Institut für Klinische Mikrobiologie, Immunologie und Hygiene
Prof. Dr. Christian Bogdan
Wasserturmstraße 3-5
D-91054 Erlangen, Germany
Contact person
Prof. Dr. Christian Bogdan
Research group leader, head of the institute and spokesman of RTG 2740
Tel. +49-9131-853-2561
Dr. Ilka Knippertz
Scientific Managing
Tel.: +49-9131 85-3571
Prof. Dr. Christian Bogdan
Research group leader, head of the institute and spokesman of RTG 2740
Tel. +49-9131-853-2561
Dr. Ilka Knippertz
Scientific Managing
Tel.: +49-9131 85-3571
PhD position (m/f/x) (for 3 years)
Published since: 02.08.2024Job-Id: 8747
Prof. Dr. Christian Bogdan
Research group leader, head of the institute and spokesman of RTG 2740
Tel. +49-9131-853-2561
Dr. Ilka Knippertz
Scientific Managing
Tel.: +49-9131 85-3571
Research group leader, head of the institute and spokesman of RTG 2740
Tel. +49-9131-853-2561
Dr. Ilka Knippertz
Scientific Managing
Tel.: +49-9131 85-3571
Universitätsklinikum Erlangen
Institut für Klinische Mikrobiologie, Immunologie und Hygiene
Prof. Dr. Christian Bogdan
Wasserturmstraße 3-5
D-91054 Erlangen, Germany
Institut für Klinische Mikrobiologie, Immunologie und Hygiene
Prof. Dr. Christian Bogdan
Wasserturmstraße 3-5
D-91054 Erlangen, Germany
PhD position (m/f/x) (for 3 years)
Published since: 02.08.2024
Job-Id: 8747
Prof. Dr. Christian Bogdan
Research group leader, head of the institute and spokesman of RTG 2740
Tel. +49-9131-853-2561
Dr. Ilka Knippertz
Scientific Managing
Tel.: +49-9131 85-3571
Published since: 02.08.2024
Job-Id: 8747
Universitätsklinikum Erlangen
Institut für Klinische Mikrobiologie, Immunologie und Hygiene
Prof. Dr. Christian Bogdan
Wasserturmstraße 3-5
D-91054 Erlangen, Germany
Contact personInstitut für Klinische Mikrobiologie, Immunologie und Hygiene
Prof. Dr. Christian Bogdan
Wasserturmstraße 3-5
D-91054 Erlangen, Germany
Prof. Dr. Christian Bogdan
Research group leader, head of the institute and spokesman of RTG 2740
Tel. +49-9131-853-2561
Dr. Ilka Knippertz
Scientific Managing
Tel.: +49-9131 85-3571
Sounds interesting?
Who we are:
The Research Training Group (RTG; Graduiertenkolleg, GRK) 2740 "ImmunoMicroTope", which has started in January 2022, is a research consortium funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation). It is run by 15 outstanding research group leaders located in Erlangen, Regensburg and Cologne. The RTG 2740 focuses on the in situ analysis of the tissue microenvironment, the micromilieu factors and the metabolites that determine the immune response against bacterial, parasitic and fungal pathogens. The overarching goal of the consortium is the characterization of the complex "immunomicrotope" during infections (Bogdan et al., Trends in Parasitology Sep. 2024, in press).
Your tasks:
In previous studies, Prof. Bogdan's group has shown that hyperexpression of arginase 1 (Arg1) is responsible for the non-healing course of cutaneous leishmaniasis, a chronic infection caused by the protozoan parasite Leishmania. Myeloid cells co-expressing Arg1 and inducible nitric oxide synthase (NOS2) form a replicative niche for Leishmania parasites. In recent analyses, the availability of L-arginine at the site of skin infection has been found to be crucial for the development of a protective anti-Leishmania immune response and the healing of skin lesions.
The current project aims to elucidate the molecular effects of L-arginine on the transcriptome, metabolome and function of various immune and mesenchymal cells as well as the skin microbiota during cutaneous leishmaniasis.
For more information, please visit www.immunomicrotope.de
Comments:
- The program starts on January 1st 2025
- The PhD position is available for initially 36 months
- Pay grade is determined according to the qualifications and personal requirements as defined by TV-L E13
- Please provide a single PDF file (last name_first name.pdf) consisting of the following documents in English language:
- Completed application form (RTG 2740 Application form_PhD; www.immunomicrotope.de)
- Curriculum vitae
- Letter of motivation
- One-page summary each of the bachelor and master thesis
- Copies of the university entrance exam, Bachelor exam and Master exam
- Two letters of reference
- Other credentials and information relevant to the RTG2740 program
Essential experience/qualifications:
- Master’s Degree (or equivalent) in life sciences
- Excellent academic performance
- Practical and theoretic experience in the field of immunology, molecular biology, cell biology and/or parasitology
- Basic knowledge in mammalian cell culture, molecular biology methods (e.g., RNA/DNA isolation, quantitative PCR, bulk and scRNAseq, Western blot, ChIP), immunohistochemistry and fluorescence (confocal) microscopy
- Enthusiasm for experimental work and for further developing experimental techniques
- High level of scientific interest
- Very good English language skills
- Proficiency in MS Office, Excel, Prism
- Team spirit
- Sense of responsibility, initiative, ambition, motivation and determination
Additionally beneficial are:
- Experience in the field of parasitology
- Experience with experimental in vivo models
- Experience in mammalian cell culture
- Experience with imaging methods
- Experience in bioinformatic analyses
- FELASA B certificate